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BTA is known in a number of forms. For example, BTA can be denatured by heat or by treating with a chemical or ionic agent. The denatured form of the toxin, which is commercially available, is referred to as “Onabotulinum toxin type A” or “ONA”. The non-denatured form of the toxin, referred to as “Immobilised BTA”, is a complex comprising toxin bound to a water soluble polymer, in this case, to a polysaccharide polymer (e.g. poly-L-aspartic acid).
A major drawback of conventional botulinum toxin based therapy is that a single treatment with botulinum toxin is only effective for a short duration. Botulinum toxin treatments are repeated periodically to maintain a therapeutic level of the toxin in the body. In order to treat the entire surface area of the body with botulinum toxin, multiple injections of relatively large amounts of toxin (on the order of milligrams per muscle) are required. This is problematic because local injections are painful, even for patients that are properly anaesthetised, and repeated injections are generally accompanied by pain at the site of administration. Furthermore, such repeated injections may be difficult to administer in many locations such as the face, which has a number of important functions. For example, muscles around the eyes are necessary for the movement of the eyes, and muscles around the nose and mouth are necessary for the operation of the mouth. There is a need for an improved method of delivering botulin
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